Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens
نویسندگان
چکیده
CD3+ T lymphocytes expressing neither CD4 nor CD8 antigens exist in normal human peripheral blood in low frequency (approximately 3% of lymphocytes). The CD3+,4-,8- phenotype was stably maintained after in vitro culture in IL-2. Culture of CD3+,4-,8- cells in only rIL-2 generated cytotoxic T cells that lysed NK-sensitive and NK-insensitive tumor cell targets without MHC restriction. These experiments clearly show that phenotypically and functionally competent T cells expressing neither CD4 nor CD8 are present in normal peripheral blood.
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Brief Definitive Report Human Cd3 + T Lymphocytes That Express Neither Cd4 nor Cd8 Antigens
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 164 شماره
صفحات -
تاریخ انتشار 1986